Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) …

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

Metabolic disruptions that occur widely in cancers offer an attractive focus for generalized
treatment strategies. The hexosamine biosynthetic pathway (HBP) senses metabolic status …

Glycosyltransferases are ubiquitous enzymes that catalyze the assembly of glycoconjugates
throughout all kingdoms of nature. A long-standing problem is the rational design of probes …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational
modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear …

O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification,
occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …

Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in
obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of …

The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …