Diffuse large B-cell lymphoma

LH Sehn, G Salles - New England Journal of Medicine, 2021 - Mass Medical Soc
Diffuse Large B-Cell Lymphoma DLBCL, an aggressive cancer, accounts for about 30% of
all lymphomas. Empirical combination chemotherapy cures about 65% of patients initially …

Diffuse large B-cell lymphoma: R-CHOP failure—what to do?

B Coiffier, C Sarkozy - Hematology 2014, the American Society …, 2016 - ashpublications.org
Although rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-
CHOP) is the standard treatment for patients with diffuse large B-cell lymphoma (DLBCL),∼ …

Dose-adjusted EPOCH-R compared with R-CHOP as frontline therapy for diffuse large B-cell lymphoma: clinical outcomes of the phase III intergroup trial alliance …

NL Bartlett, WH Wilson, SH Jung, ED Hsi… - Journal of clinical …, 2019 - ascopubs.org
PURPOSE Alliance/CALGB 50303 (NCT00118209), an intergroup, phase III study,
compared dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide …

CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP

N Schmitz, S Zeynalova, M Nickelsen… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To develop and validate a risk score for relapse in the CNS in patients with diffuse
large B-cell lymphoma (DLBCL). Patients and Methods A total of 2,164 patients (18 to 80 …

Double hit and double expressors in lymphoma: definition and treatment

PA Riedell, SM Smith - Cancer, 2018 - Wiley Online Library
Emerging biologic subsets and new prognostic markers are significantly and adversely
affecting curability after standard chemoimmunotherapy for aggressive B‐cell lymphomas …

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma

JL Rubenstein, H Geng, EJ Fraser, P Formaker… - Blood …, 2018 - ashpublications.org
There is an unmet need for effective biological therapies for relapsed central nervous system
(CNS) lymphoma. Lenalidomide is active in activated B-cell type diffuse large B-cell …

Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions

VM Orellana-Noia, DR Reed… - Blood, The Journal …, 2022 - ashpublications.org
Prophylaxis is commonly used to prevent central nervous sy stem (CNS) relapse in diffuse
large B-cell lymphoma (DLBCL), with no clear standard of care. We retrospectively …

High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma

A Rosenthal, A Younes - Blood reviews, 2017 - Elsevier
Diffuse large B-cell lymphomas with aberrations in MYC, BCL2 and/or BCL6 by genetic
alterations or protein expression represent a group of high grade B-cell lymphomas with …

[HTML][HTML] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

SE Arthur, A Jiang, BM Grande, M Alcaide… - Nature …, 2018 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-
cells. Prognosis is strongly associated with molecular subgroup, although the driver …

Extranodal diffuse large B cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence

TA Ollila, AJ Olszewski - Current treatment options in oncology, 2018 - Springer
Opinion statement Diffuse large B cell lymphoma (DLBCL) arises from extranodal organs in
about 30% of cases. Its prognosis and risk of recurrence in the central nervous system …