Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Objective The role of testosterone (T) in regulating body composition is conflicting. Thus, our
goal is to meta-analyse the effects of T supplementation (TS) on body composition and …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

Obesity and male hypogonadism (HG) are often associated, as demonstrated in all cross-
sectional studies. Prospective studies have indicated that i) having HG at baseline increases …

Background Potential cardiovascular (CV) risks of testosterone replacement therapy (TRT)
are currently a topic of intense interest. However, no studies have addressed CV risk as a …

Objective We developed clinical practice guidelines to assess the individual risk–benefit
profile of androgen replacement therapy in adult male hypogonadism (HG), defined by the …

Given the conflicting evidence regarding the association between exogenous testosterone
and cardiovascular events, we systematically assessed published systematic reviews for …

The sexual dimorphism in human body fat distribution suggests a causal role for sex
hormones. This is of particular importance when considering the role of excess visceral …

Testosterone replacement therapy (TRT) has been used in millions of men worldwide to
treat diminished libido and erectile dysfunction, and to improve strength and physical …