echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

Personalized medicine is a broad and rapidly advancing field of health care that is informed
by each person's unique clinical, genetic, genomic, and environmental information …

Recent studies have evaluated whether incorporating nontraditional risk factors improves
coronary heart disease (CHD) prediction models. This 1986–2001 US study aggregated the …

Atherosclerotic cardiovascular disease (CVD) is a major health problem in the United States
and around the world. Evidence accumulated over decades convincingly demonstrates that …

Background Cardiovascular disease (CVD) and its most common manifestations–including
coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF)–are major …

Atherosclerotic involvement in the coronary arteries, which can result in heart attack and
sudden death, is a common disease and prototypic of a complex human trait. To understand …

Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling
receptor that is widely expressed. In the liver, LRP1 plays an important role in regulating the …

Oxidative stress leads to vascular damage and participates in the pathomechanisms of
aortic dissection and aneurysm formation. Here we study aortic dissection in mice deficient …