The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

Cell migration plays a central role in many physiological and pathophysiological processes,
such as embryogenesis, immune defense, wound healing, or the formation of tumor …

▪ Abstract In contrast to the airways, the defects in colonic function in cystic fibrosis (CF)
patients are closely related to the defect in CFTR. The gastrointestinal phenotype of CF …

Cl− secretion in the colon can be activated by an increase of either intracellular Ca2+ or
cAMP. In this study we examined a possible interdependence of the two second-messenger …

The antifungal antibiotic clotrimazole (CLT) blocks directly and with high potency the Ca2+-
activated K+ channels of human erythrocytes, erythroleukemia cells, and ferret vascular …

K+ secretion in the kidney and distal colon is a main determinant of K+ homeostasis. This
study investigated the identity of the relevant luminal secretory K+ ion channel in distal …

Homeostatic control of plasma K+ is a necessary physiological function. The daily dietary K+
intake of~ 100 mmol is excreted predominantly by the distal tubules of the kidney. About …

Colonic crypt cells possess basolateral Ca 2+-regulated K+ channels which support Cl–
secretion by providing the necessary driving force. The pharmacological characteristics of …

Extracellular nucleotides are important regulators of epithelial ion transport. Here we
investigated nucleotide-mediated effects on colonic NaCl secretion and the signal …