Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases
Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …
Understanding the tumor microenvironment for effective immunotherapy
H Sadeghi Rad, J Monkman… - Medicinal research …, 2021 - Wiley Online Library
Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …
patients across a number of solid tumor types. Understanding of the subsets of patients that …
Mast cells link immune sensing to antigen-avoidance behaviour
The physiological functions of mast cells remain largely an enigma. In the context of barrier
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …
New perspectives on the origins and heterogeneity of mast cells
Mast cells are immune cells of the haematopoietic lineage that are now thought to have
multifaceted functions during homeostasis and in various disease states. Furthermore, while …
multifaceted functions during homeostasis and in various disease states. Furthermore, while …
[HTML][HTML] Mast cells as a unique hematopoietic lineage and cell system: from Paul Ehrlich's visions to precision medicine concepts
P Valent, C Akin, K Hartmann, G Nilsson, A Reiter… - Theranostics, 2020 - ncbi.nlm.nih.gov
The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …
The ingenious mast cell: Contemporary insights into mast cell behavior and function
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease
Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA
Rapid neutrophil recruitment to sites of inflammation is crucial for innate immune responses.
Here, we reveal that the G-protein-coupled receptor GPR35 is upregulated in activated …
Here, we reveal that the G-protein-coupled receptor GPR35 is upregulated in activated …
Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies
H Kühn, P Kolkhir, M Babina, M Düll… - Journal of Allergy and …, 2021 - Elsevier
The Mas-related G protein–coupled receptor X2 (MRGPRX2) is a multiligand receptor
responding to various exogenous and endogenous stimuli. Being highly expressed on skin …
responding to various exogenous and endogenous stimuli. Being highly expressed on skin …
[HTML][HTML] Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases
Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …