Glioblastoma: current status, emerging targets, and recent advances

A Thakur, C Faujdar, R Sharma, S Sharma… - Journal of Medicinal …, 2022 - ACS Publications
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

[HTML][HTML] Current evidence and future perspectives in the medical management of vascular Ehlers–Danlos syndrome: focus on vascular prevention

G Buso, F Corvini, EM Fusco, M Messina… - Journal of Clinical …, 2024 - mdpi.com
Vascular Ehlers–Danlos syndrome (vEDS) is a rare autosomal dominant connective tissue
disease resulting from pathogenic variants in the collagen type III alpha 1 chain (COL3A1) …

Glioblastoma stem cells—useful tools in the battle against cancer

SMB Rodriguez, GA Staicu, AS Sevastre… - International Journal of …, 2022 - mdpi.com
Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …

EGFR alterations in glioblastoma play a role in antitumor immunity regulation

XP Li, ZQ Guo, BF Wang, M Zhao - Frontiers in oncology, 2023 - frontiersin.org
The epidermal growth factor receptor (EGFR) is the most frequently altered gene in
glioblastoma (GBM), which plays an important role in tumor development and anti-tumor …

Neurotransmitters: potential targets in Glioblastoma

Q Huang, L Chen, J Liang, Q Huang, H Sun - Cancers, 2022 - mdpi.com
Simple Summary Aiming to discover potential treatments for GBM, this review connects
emerging research on the roles of neurotransmitters in the normal neural and the GBM …

Prognostic value and immune relevancy of a combined autophagy-, apoptosis-and necrosis-related gene signature in glioblastoma

Y Bi, ZH Wu, F Cao - BMC cancer, 2022 - Springer
Background Glioblastoma (GBM) is considered the most malignant and devastating
intracranial tumor without effective treatment. Autophagy, apoptosis, and necrosis, three …

Identification of protein kinase C beta as a therapeutic target for neuroendocrine prostate cancer and development of a nanoparticle-based therapeutic strategy

Y Qie, Z Cheng, Z Wu, F Qi, B Li, S Wu, T Chu, Z Lu… - Nano Today, 2023 - Elsevier
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of malignant
prostate cancer for which there is no effective treatment. Although protein kinases are the …

Magnolol induces the extrinsic/intrinsic apoptosis pathways and inhibits STAT3 signaling-mediated invasion of glioblastoma cells

PF Yueh, YH Lee, CY Fu, CB Tung, FT Hsu, KL Lan - Life, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common form of malignant brain tumor, with poor
prognosis; the efficacy of current standard therapy for GBM remains unsatisfactory …

A Multimodel Study of the Role of Novel PKC Isoforms in the DNA Integrity Checkpoint

S Saiz-Baggetto, L Dolz-Edo, E Méndez… - International Journal of …, 2023 - mdpi.com
The protein kinase C (PKC) family plays important regulatory roles in numerous cellular
processes. Saccharomyces cerevisiae contains a single PKC, Pkc1, whereas in mammals …

Alterations of the gut microbiome in recurrent malignant gliomas patients received bevacizumab and temozolomide combination treatment and temozolomide …

J Zhu, J Su - Indian Journal of Microbiology, 2022 - Springer
This case-control study explored compositions of gut microbiome in recurrent malignant
gliomas patients who had received bevacizumab and Temozolomide combination treatment …