Proteases involved in leader peptide removal during RiPP biosynthesis
SM Eslami, WA van der Donk - ACS Bio & Med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …
much attention in recent years because of their promising bioactivities and the portability of …
[PDF][PDF] Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides
Y Fu, Y Xu, F Ruijne, OP Kuipers - FEMS Microbiology Reviews, 2023 - academic.oup.com
Natural bioactive peptide discovery is a challenging and time-consuming process. However,
advances in synthetic biology are providing promising new avenues in peptide engineering …
advances in synthetic biology are providing promising new avenues in peptide engineering …
Bacterial Cytochrome P450 Catalyzed Post‐translational Macrocyclization of Ribosomal Peptides
Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …
fascinating group of natural products that exhibit diverse structural features and bioactivities …
[HTML][HTML] Unravelling the secondary metabolome and biocontrol potential of the recently described species Bacillus nakamurai
F Nimbeshaho, G Nihorimbere, AA Arias… - Microbiological …, 2024 - Elsevier
In the prospect of novel potential biocontrol agents, a new strain BDI-IS1 belonging to the
recently described Bacillus nakamurai was selected for its strong in vitro antimicrobial …
recently described Bacillus nakamurai was selected for its strong in vitro antimicrobial …
Refactoring and Heterologous Expression of Class III Lanthipeptide Biosynthetic Gene Clusters Lead to the Discovery of N,N-Dimethylated Lantibiotics from …
Class III lanthipeptides are an emerging subclass of lanthipeptides, representing an
underexplored trove of new natural products with potentially broad chemical diversity and …
underexplored trove of new natural products with potentially broad chemical diversity and …
Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates
Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …
worldwide. Ribosomally synthesized and post-translationally modified peptides have …
Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters
H Put, H Gerstmans, HV Capelle, M Fauvart… - Natural Product …, 2024 - pubs.rsc.org
Covering: up to October 2023Many bioactive natural products are synthesized by
microorganisms that are either difficult or impossible to cultivate under laboratory conditions …
microorganisms that are either difficult or impossible to cultivate under laboratory conditions …
Facile Method for Determining Lanthipeptide Stereochemistry
Lanthipeptides make up a large group of natural products that belong to the ribosomally
synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides contain …
synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides contain …
Uncovering Untapped Carboxylic Acid Reductases (CARs) for One-Step Biosynthesis and Diversification of Bioactive Nitrogen-Containing Heterocycles
Nitrogen-containing heterocycles (N-heterocycles) are essential in drug discovery, with a
majority of best-selling small-molecule drugs containing at least one N-heterocycle. Various …
majority of best-selling small-molecule drugs containing at least one N-heterocycle. Various …
[HTML][HTML] Genomic and Metabolomic Insights into the Modes-of-Action of Bacterial Strains to Control the Grapevine wood Pathogen, Fomitiporia mediterranea
Grapevine trunk diseases (GTDs), particularly Esca, represent a major challenge for
viticulture worldwide, leading to substantial economic losses. With no effective control …
viticulture worldwide, leading to substantial economic losses. With no effective control …