In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

The original paradigm of classical-also referred to as canonical-cellular signal transduction
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …

The position of the mitotic spindle determines the plane of cell cleavage, and thereby
daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated …

Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of
heterotrimeric G protein α subunits. The Ric-8A isoform chaperones Gαi/o, Gα12/13, and …

EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs).
However, the responses are not durable, and the magnitude of tumor regression is variable …

Heterotrimeric G proteins are key molecular switches that control cell behavior. The
canonical activation of G proteins by agonist-occupied G protein-coupled receptors (GPCRs) …

Epidermal growth factor receptor (EGFR) mutations are the molecular driver of a subset of
non-small cell lung cancers (NSCLC); tumors that harbor these mutations are often …

Resistance to inhibitors of cholinesterase 8A (Ric8A) is an essential regulator of G protein α-
subunits (Gα), acting as a guanine nucleotide exchange factor and a chaperone. We report …

Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates
heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone …

Summary Ric-8A is a 530-amino acid cytoplasmic molecular chaperone and guanine
nucleotide exchange factor (GEF) for i, q, and 12/13 classes of heterortrimeric G protein …