[HTML][HTML] Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology
Recent years have seen an increased understanding of the importance of myelination in
healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic …
healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic …
Promise and pitfalls of g-ratio estimation with MRI
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …
In vivo histology of the myelin g-ratio with magnetic resonance imaging
The myelin g-ratio, defined as the ratio between the inner and the outer diameter of the
myelin sheath, is a fundamental property of white matter that can be computed from a simple …
myelin sheath, is a fundamental property of white matter that can be computed from a simple …
Mapping myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures
The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been
successfully applied at the cortical level since 2011 and is now one of the most used myelin …
successfully applied at the cortical level since 2011 and is now one of the most used myelin …
Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship
M Andersson, HM Kjer… - Proceedings of the …, 2020 - National Acad Sciences
Axonal conduction velocity, which ensures efficient function of the brain network, is related to
axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion …
axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion …
Ultrastructural axon–myelin unit alterations in multiple sclerosis correlate with inflammation
AMR van den Bosch, S Hümmert, A Steyer… - Annals of …, 2023 - Wiley Online Library
Objective Changes in the normal‐appearing white matter (NAWM) in multiple sclerosis (MS)
may contribute to disease progression. Here, we systematically quantified ultrastructural and …
may contribute to disease progression. Here, we systematically quantified ultrastructural and …
Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex
Recent years have seen a growing interest in relating MRI measurements to the structural-
biophysical properties of white matter fibers. The fiber g-ratio, defined as the ratio between …
biophysical properties of white matter fibers. The fiber g-ratio, defined as the ratio between …
Sound-evoked activity influences myelination of brainstem axons in the trapezoid body
JL Sinclair, MJ Fischl, O Alexandrova… - Journal of …, 2017 - Soc Neuroscience
Plasticity of myelination represents a mechanism to tune the flow of information by balancing
functional requirements with metabolic and spatial constraints. The auditory system is …
functional requirements with metabolic and spatial constraints. The auditory system is …
[HTML][HTML] Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging
Optimal myelination of neuronal axons is essential for effective brain and cognitive function.
The ratio of the axon diameter to the outer fiber diameter, known as the g-ratio, is a reliable …
The ratio of the axon diameter to the outer fiber diameter, known as the g-ratio, is a reliable …
[HTML][HTML] Characterizing axonal myelination within the healthy population: a tract-by-tract mapping of effects of age and gender on the fiber g-ratio
The g-ratio, equal to the ratio of the inner-to-outer diameter of a myelinated axon, is
associated with the speed of conduction, and thus reflects axonal function and integrity. It is …
associated with the speed of conduction, and thus reflects axonal function and integrity. It is …