Multi-drug resistant gram-negative bacterial pneumonia: etiology, risk factors, and drug resistance patterns

M Assefa - Pneumonia, 2022 - Springer
Bacterial pneumonia is one of the most serious public health issues owing to its medical and
economic costs, which result in increased morbidity and mortality in people of all ages …

The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

[HTML][HTML] Pseudomonas aeruginosa: Infections and novel approaches to treatment “Knowing the enemy” the threat of Pseudomonas aeruginosa and exploring novel …

N Sathe, P Beech, L Croft, C Suphioglu, A Kapat… - Infectious Medicine, 2023 - Elsevier
Pseudomonas aeruginosa is an aerobic Gram-negative rod-shaped bacterium with a
comparatively large genome and an impressive genetic capability allowing it to grow in a …

Subunit vaccines for Acinetobacter baumannii

N Yang, X Jin, C Zhu, F Gao, Z Weng, X Du… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen
in hospitals. A. baumannii infection has become a challenging problem in clinical practice …

An unnatural amino acid dependent, conditional Pseudomonas vaccine prevents bacterial infection

M Pigula, YC Lai, M Koh, CS Diercks… - Nature …, 2024 - nature.com
Live vaccines are ideal for inducing immunity but suffer from the need to attenuate their
pathogenicity or replication to preclude the possibility of escape. Unnatural amino acids …

Vaccine development for bacterial pathogens: Advances, challenges and prospects

IE Mba, HC Sharndama… - Tropical Medicine & …, 2023 - Wiley Online Library
The advent and use of antimicrobials have played a key role in treating potentially life‐
threatening infectious diseases, improving health, and saving the lives of millions of people …

Proteomic approach to identify host cell attachment proteins provides protective Pseudomonas aeruginosa vaccine antigen FtsZ

I Jurado-Martín, J Tomás-Cortázar, Y Hou… - npj Vaccines, 2024 - nature.com
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes severe
nosocomial infections in susceptible individuals due to the emergence of multidrug-resistant …

Defining the mechanistic correlates of protection conferred by whole-cell vaccination against Pseudomonas aeruginosa acute murine pneumonia

E Sen-Kilic, CB Blackwood, AB Huckaby… - Infection and …, 2021 - Am Soc Microbiol
Pseudomonas aeruginosa is a Gram-negative pathogen that causes severe pulmonary
infections associated with high morbidity and mortality in immunocompromised patients. The …

Immune responses to bacterial lung infections and their implications for vaccination

V Muruganandah, A Kupz - International Immunology, 2022 - academic.oup.com
The pulmonary immune system plays a vital role in protecting the delicate structures of
gaseous exchange against invasion from bacterial pathogens. With antimicrobial resistance …