Increasing use of chimeric antigen receptor T-cell therapy (CAR-T) has unveiled diverse
toxicities warranting specific recognition and management. Cytopenias occurring after CAR …

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant …

Hematotoxicity represents a frequent chimeric antigen receptor (CAR) T-cell–related
adverse event and remains poorly understood. In this multicenter analysis, we studied …

Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …

Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …

The mRNA N 6-methyladenosine (m6A) modification has emerged as an essential regulator
of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2 …

Bacterial infection leads to consumption of short-lived innate immune effector cells, which
then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs …

Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the
development and function of the immune system. TLR signaling promotes the earliest …

Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-
intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and …