Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications

Z Li, Y Jiang, FP Guengerich, L Ma, S Li… - Journal of Biological …, 2020 - ASBMB
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

Progress in biopharmaceutical development

M Kesik‐Brodacka - Biotechnology and applied biochemistry, 2018 - Wiley Online Library
Since its introduction in 1982, biopharmaceutical drugs have revolutionized the treatment of
a broad spectrum of diseases and are increasingly used in nearly all branches of medicine …

Structural diversity, functional aspects and future therapeutic applications of human gut microbiome

S Ghosh, S Pramanik - Archives of microbiology, 2021 - Springer
The research on human gut microbiome, regarded as the black box of the human body, is
still at the stage of infancy as the functional properties of the complex gut microbiome have …

Progress in enzyme immobilization in ordered mesoporous materials and related applications

Z Zhou, M Hartmann - Chemical Society Reviews, 2013 - pubs.rsc.org
A short time after the discovery of ordered mesoporous materials, which possess unique
features such as high specific surface area and pore volume, highly uniform pore distribution …

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

R Bernhardt, VB Urlacher - Applied microbiology and biotechnology, 2014 - Springer
Cytochromes P450 (CYPs) belong to the superfamily of heme b containing
monooxygenases with currently more than 21,000 members. These enzymes accept a vast …

Hydrogen peroxide driven biocatalysis

BO Burek, S Bormann, F Hollmann, JZ Bloh… - Green …, 2019 - pubs.rsc.org
In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded
as the ultimate “green” reagent because water and oxygen are the only by-products …

NSAIDs and cardiovascular diseases: role of reactive oxygen species

R Ghosh, A Alajbegovic… - Oxidative medicine and …, 2015 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most commonly used drugs
worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis …

Design and engineering of artificial oxygen-activating metalloenzymes

F Nastri, M Chino, O Maglio… - Chemical Society …, 2016 - pubs.rsc.org
Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …

Natural compounds as pharmaceuticals: the key role of cytochromes P450 reactivity

G Di Nardo, G Gilardi - Trends in Biochemical Sciences, 2020 - cell.com
The design of drugs from natural products is a re-emerging area due to the need for
bioactive compounds. The exploitation of natural products and their derivatives obtained by …

Biotransformation: impact and application of metabolism in drug discovery

J Shanu-Wilson, L Evans, S Wrigley… - ACS Medicinal …, 2020 - ACS Publications
Biotransformation has a huge impact on the efficacy and safety of drugs. Ultimately the
effects of metabolism can be the lynchpin in the discovery and development cycle of a new …