Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled
immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in …

The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs)
presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic …

Histone acetylation is generally associated with active chromatin, but most studies have
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …

Numerous studies in multiple systems support that histone H3 lysine 36 dimethylation
(H3K36me2) is associated with transcriptional activation; however, the underlying …

Enhancers control development and cellular function by spatiotemporal regulation of gene
expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono …

Hearing disorders constitute one of the major health concerns in the USA. Decades of basic
and clinical studies have identified numerous ototoxic agents and investigated their modes …

The transcriptional co-activator lens epithelium-derived growth factor/p75 (LEDGF/p75)
plays an important role in the biology of the cell and in several human diseases, including …

Functional crosstalk between histone modifications and chromatin remodeling has emerged
as a key regulatory mode of transcriptional control during cell fate decisions, but the …

Reef structural complexity provides important refuge habitat for a range of marine
organisms, and is a useful indicator of the health and resilience of reefs as a whole. Marine …

ABSTRACT HIV integration occurs in chromatin sites that favor the release of high levels of
viral progeny; alternatively, the virus is also able to discreetly coexist with the host. The viral …