The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Natural products represent a rich reservoir of potential small chemical molecules exhibiting
antiproliferation and anticancer properties. An example is berberine, a protoberberine …

Berberine (BBR) has been shown to improve several metabolic disorders, such as obesity,
type 2 diabetes, and dyslipidemia, by stimulating AMP-activated protein kinase (AMPK) …

Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-
established karaviloside XI, were isolated from the vegetable bitter melon (Momordica …

To discover and develop novel natural compounds, active ingredients, single herbs and
combination formulas or prescriptions in traditional Chinese medicine (TCM) with …

Most malaria drug development focuses on parasite stages detected in red blood cells, even
though, to achieve eradication, next-generation drugs active against both erythrocytic and …

Abstract Ischemia/reperfusion (I/R)-induced autophagy increases the severity of
cardiomyocyte injury. The aim of this study was to investigate the effects of berberine, a …

Berberis vulgaris and berberine, its main component, traditionally have been used for
treatment of various disorders. The pharmacological properties of them have been …

Inflammation is a known mediator of adverse ventricular remodeling after myocardial
infarction (MI) that may lead to reduction of ejection fraction and subsequent heart failure …

With the accelerated aging of human society Alzheimer's disease (AD) has become one of
the most threatening diseases in the elderly. However, there is no efficient therapeutic agent …