Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics

MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

WH Müller, A Verdin, E De Pauw… - Mass Spectrometry …, 2022 - Wiley Online Library
In the last decades, surface‐assisted laser desorption/ionization mass spectrometry (SALDI‐
MS) has attracted increasing interest due to its unique capabilities, achievable through the …

Lipid imaging by mass spectrometry–a review

D Gode, DA Volmer - Analyst, 2013 - pubs.rsc.org
Mass spectrometry imaging (MSI) has proven to be extremely useful for applications such as
the spatial analysis of peptides and proteins in biological tissue, the performance …

Recent advances in single-cell analysis by mass spectrometry

L Yin, Z Zhang, Y Liu, Y Gao, J Gu - Analyst, 2019 - pubs.rsc.org
Cells are the most basic structural units that play vital roles in the functioning of living
organisms. Analysis of the chemical composition and content of a single cell plays a vital …

Perspective on advances in laser-based high-resolution mass spectrometry imaging

T Wang, X Cheng, H Xu, Y Meng, Z Yin, X Li… - Analytical …, 2019 - ACS Publications
Mass spectrometry imaging (MSI) has become a powerful tool in diverse fields, such as
chemistry, physics, materials, and life science. Although such research is getting more …

Molecular imaging of biological samples on nanophotonic laser desorption ionization platforms

SA Stopka, C Rong, AR Korte… - Angewandte Chemie …, 2016 - Wiley Online Library
Mass spectrometry imaging (MSI) is a comprehensive tool for the analysis of a wide range of
biomolecules. The mainstream method for molecular MSI is matrix‐assisted laser desorption …

Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade

WH Müller, E De Pauw, J Far, C Malherbe… - Progress in Lipid …, 2021 - Elsevier
Knowing the spatial location of the lipid species present in biological samples is of
paramount importance for the elucidation of pathological and physiological processes. In …

Surface analysis of lipids by mass spectrometry: more than just imaging

SR Ellis, SH Brown, M in het Panhuis… - Progress in lipid …, 2013 - Elsevier
Mass spectrometry is now an indispensable tool for lipid analysis and is arguably the driving
force in the renaissance of lipid research. In its various forms, mass spectrometry is uniquely …

Signal preprocessing, multivariate analysis and software tools for MA (LDI)‐TOF mass spectrometry imaging for biological applications

P Ràfols, D Vilalta, J Brezmes… - Mass spectrometry …, 2018 - Wiley Online Library
Mass spectrometry imaging (MSI) is a label‐free analytical technique capable of molecularly
characterizing biological samples, including tissues and cell lines. The constant …

Brain region mapping using global metabolomics

J Ivanisevic, AA Epstein, ME Kurczy, PH Benton… - Chemistry & biology, 2014 - cell.com
Historically, studies of brain metabolism have been based on targeted analyses of a limited
number of metabolites. Here we present an untargeted mass spectrometry-based …