Nanodiscoidal Nucleic Acids for Gene Regulation
Therapeutic nucleic acids represent a powerful class of drug molecules to control gene
expression and protein synthesis. A major challenge in this field is that soluble …
expression and protein synthesis. A major challenge in this field is that soluble …
Apolipoprotein AI: Potential Protection Against Intestinal Injury Induced by Dietary Lipid
JX Wang, SJ Yu, G Huang, YB Yu… - Journal of Inflammation …, 2024 - Taylor & Francis
The intestinal barrier system protects the human body from harmful factors, by continuously
renewing the intestinal epithelium, tight junctions and enteric microbes. However, dietary fat …
renewing the intestinal epithelium, tight junctions and enteric microbes. However, dietary fat …
Systematic evaluation of lecithin: Cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: Regulatory role of charged residues at …
A Niemelä, A Koivuniemi - PLOS Computational Biology, 2024 - journals.plos.org
Lecithin: cholesterol acyltransferase (LCAT) exhibits α-activity on high-density and β-activity
on low-density lipoproteins. However, the molecular determinants governing LCAT …
on low-density lipoproteins. However, the molecular determinants governing LCAT …
Development of activated endothelial targeted high-density lipoprotein nanoparticles
Endothelial inflammation is an important pathophysiological driving force in various acute
and chronic inflammatory diseases. High-density lipoproteins (HDLs) play critical roles in …
and chronic inflammatory diseases. High-density lipoproteins (HDLs) play critical roles in …
Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations
S Ciro Acosta, L Díaz-Ordóñez… - The Application of …, 2024 - Taylor & Francis
Mutations in the lecithin-cholesterol acyltransferase (LCAT) gene, which catalyzes the
esterification of cholesterol, result in two types of autosomal recessive disorders: Familial …
esterification of cholesterol, result in two types of autosomal recessive disorders: Familial …
Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: a 45 years bibliometrics analysis
Background: Lecithin cholesterol acyltransferase (LCAT) is an important enzyme
responsible for free cholesterol (FC) esterification, which is critical for high density …
responsible for free cholesterol (FC) esterification, which is critical for high density …