Cancer/testis antigens: promising immunotherapy targets for digestive tract cancers

H Ai, H Yang, L Li, J Ma, K Liu, Z Li - Frontiers in Immunology, 2023 - frontiersin.org
Digestive tract cancers, including esophageal, gastric, and colorectal cancers, are the major
cause of death among cancer patients worldwide due to the heterogeneity of cancer cells …

[HTML][HTML] Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy

Y Li, C Zhang, G Li, G Deng, H Zhang, Y Sun… - … Pharmaceutica Sinica B, 2021 - Elsevier
Proteases have a fundamental role in maintaining physiological homeostasis, but their
dysregulation results in severe activity imbalance and pathological conditions, including …

Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

H Li, W Zhang, M Yan, J Qiu, J Chen, X Sun… - Journal of Experimental …, 2019 - Springer
Background The primary obstacle to treat cervical cancer is its high prevalence of
metastasis, which severely affects patients' quality of life and survival time. Nucleolar and …

Tumor suppressor lnc-CTSLP4 inhibits EMT and metastasis of gastric cancer by attenuating HNRNPAB-dependent Snail transcription

T Pan, Z Yu, Z Jin, X Wu, A Wu, J Hou, X Chang… - … Therapy-Nucleic Acids, 2021 - cell.com
Tumor metastasis is a crucial impediment to the treatment of gastric cancer (GC), and the
epithelial-to-mesenchymal transition (EMT) program plays a critical role for the initiation of …

The cancer/testis antigen HORMAD1 mediates epithelial–mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling …

K Liu, L Cheng, K Zhu, J Wang, Q Shu - Cell Death Discovery, 2022 - nature.com
The cancer/testis antigen HORMAD1 is a mechanical regulator that modulates DNA
homologous recombination repair and mismatch repair in multiple cancers. However, the …

[HTML][HTML] The cancer/testis antigen HORMAD1 promotes gastric cancer progression by activating the NF-κB signaling pathway and inducing epithelial-mesenchymal …

G Bian, W Li, D Huang, Q Zhang, X Ding… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Objectives: HORMAD1 is a cancer/testis antigen (CTAs) that regulates DNA homologous
recombination, mismatch repair, and other tumor characteristics. However, its role and …

CSNK2A1 promotes gastric cancer invasion through the PI3K-Akt-mTOR signaling pathway

C Jiang, Z Ma, G Zhang, X Yang, Q Du… - Cancer Management …, 2019 - Taylor & Francis
Objective Casein kinase 2 a1 (CSNK2A1) has been shown to be involved in tumorigenesis
by enhancing several oncogenic signaling pathways in various cancers. However, the …

TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose‐6‐phosphate dehydrogenase (G6PD)

X Zhang, F Gao, H Ai, S Wang, Z Song… - Cell …, 2021 - Wiley Online Library
Abstract Background & Aims Hepatocellular carcinoma (HCC) is a common malignant
tumour with high morbidity and mortality. Metabolic regulation by oncogenes is necessary …

Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma

B Dai, X Zhang, R Shang, J Wang, X Yang… - Cell Communication and …, 2018 - Springer
Background The molecular signaling events involving in high malignancy and poor
prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of …

[HTML][HTML] Hsa_circ_0002019 promotes cell proliferation, migration, and invasion by regulating TNFAIP6/NF-κB signaling in gastric cancer

D Chen, L Shi, D Zhong, Y Nie, Y Yang, D Liu - Genomics, 2023 - Elsevier
Background Gastric cancer (GC) is a common cancer with a high incidence and mortality
rate. Herein, the role of hsa_circ_0002019 (circ_0002019) in GC was investigated. Methods …