Yeast systems biology: model organism and cell factory
J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …
Epistasis in protein evolution
TN Starr, JW Thornton - Protein science, 2016 - Wiley Online Library
The structure, function, and evolution of proteins depend on physical and genetic
interactions among amino acids. Recent studies have used new strategies to explore the …
interactions among amino acids. Recent studies have used new strategies to explore the …
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
The E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
An Atlas of Variant Effects to understand the genome at nucleotide resolution
Sequencing has revealed hundreds of millions of human genetic variants, and continued
efforts will only add to this variant avalanche. Insufficient information exists to interpret the …
efforts will only add to this variant avalanche. Insufficient information exists to interpret the …
eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
Abstract eggNOG is a public database of orthology relationships, gene evolutionary histories
and functional annotations. Here, we present version 5.0, featuring a major update of the …
and functional annotations. Here, we present version 5.0, featuring a major update of the …
eggNOG 6.0: enabling comparative genomics across 12 535 organisms
The eggNOG (evolutionary gene genealogy Non-supervised Orthologous Groups) database
is a bioinformatics resource providing orthology data and comprehensive functional …
is a bioinformatics resource providing orthology data and comprehensive functional …
Mutation effects predicted from sequence co-variation
Many high-throughput experimental technologies have been developed to assess the
effects of large numbers of mutations (variation) on phenotypes. However, designing …
effects of large numbers of mutations (variation) on phenotypes. However, designing …
[HTML][HTML] A human interactome in three quantitative dimensions organized by stoichiometries and abundances
The organization of a cell emerges from the interactions in protein networks. The
interactome is critically dependent on the strengths of interactions and the cellular …
interactome is critically dependent on the strengths of interactions and the cellular …
Emerging and evolving concepts in gene essentiality
Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …
fundamental and applied research. Multiple screens have been performed over the years in …
Widespread expansion of protein interaction capabilities by alternative splicing
While alternative splicing is known to diversify the functional characteristics of some genes,
the extent to which protein isoforms globally contribute to functional complexity on a …
the extent to which protein isoforms globally contribute to functional complexity on a …