The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Marked changes occur in the brain during people's lives, and individual rates of aging have
revealed pronounced differences, giving rise to subject-specific brainprints that are the …

Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

The anisotropy of brain white matter microstructure manifests itself in orientational-
dependence of various MRI contrasts, and can result in significant quantification biases if …

The dependence of the diffusion MRI signal on the diffusion time carries signatures of
restricted diffusion and exchange. Here we seek to highlight these signatures in the human …

Purpose Reperfusion therapy enables effective treatment of ischemic stroke presenting
within 4–6 hours. However, tissue progression from ischemia to infarction is variable, and …

Abstract This paper presents Contextual Fibre Growth (ConFiG), an approach to generate
white matter numerical phantoms by mimicking natural fibre genesis. ConFiG grows fibres …

Evidence mounts that the steady‐state cellular water efflux (unidirectional) first‐order rate
constant (kio [s− 1]) magnitude reflects the ongoing, cellular metabolic rate of the cytolemmal …

Purpose Biophysical models of diffusion MRI have been developed to characterize
microstructure in various tissues, but existing models are not suitable for tissue composed of …

Transmembrane water exchange is a potential biomarker in the diagnosis and
understanding of cancers, brain disorders, and other diseases. Filter-exchange imaging …