2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association

SS Martin, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Genetics meets proteomics: perspectives for large population-based studies

K Suhre, MI McCarthy, JM Schwenk - Nature Reviews Genetics, 2021 - nature.com
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Systems biology in cardiovascular disease: a multiomics approach

A Joshi, M Rienks, K Theofilatos, M Mayr - Nature Reviews Cardiology, 2021 - nature.com
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

An atlas of genetic scores to predict multi-omic traits

Y Xu, SC Ritchie, Y Liang, PRHJ Timmers, M Pietzner… - Nature, 2023 - nature.com
The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice

J Liu, S Lane, R Lall, M Russo, L Farrell… - Science …, 2022 - science.org
Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is
limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast …

In aptamers they trust: caveats of the SOMAscan biomarker discovery platform from SomaLogic

A Joshi, M Mayr - Circulation, 2018 - Am Heart Assoc
Although it has become affordable to sequence the entire human genome, measuring all
proteins in a sample as complex as human plasma remains currently out of reach. The …

Unlocking the multifaceted molecular functions and diverse disease implications of lactylation

F Jing, J Zhang, H Zhang, T Li - Biological Reviews, 2024 - Wiley Online Library
In recent years, a significant breakthrough has emerged in biology, the identification of
lactylation, a novel post‐translational process. This intriguing modification is not limited to a …

Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension

L Harbaum, CJ Rhodes, J Wharton… - American Journal of …, 2022 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) is characterized by structural remodeling
of pulmonary arteries and arterioles. Underlying biological processes are likely reflected in a …