Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …

Mesenchymal stem cells (MSCs) hold great promise for the treatment of cartilage related
injuries. However, selectively promoting stem cell differentiation in vivo is still challenging …

Traditionally, bone tissue engineering has been used for creating implants for bone
regeneration, but recently, it is increasingly applied to create three-dimensional (3D) in vitro …

The recent development of bone-on-chips (BOCs) holds the main advantage of requiring a
low quantity of cells and material, compared to traditional In Vitro models. By incorporating …

Developmental engineering strategies aim to recapitulate aspects of development in vitro as
a means of forming functional engineered tissues, including cartilage and bone, for tissue …

Recent in vitro studies have revealed that the mechanobiological responses of osteoblasts
and osteocytes are fundamentally impaired during estrogen deficiency. However, these two …

Tissue engineering strategies promote bone regeneration for large bone defects by
stimulating the osteogenesis route via intramembranous ossification in engineered grafts …

A prominent feature of the skeleton is its ability to remodel in response to biophysical stimuli
and to repair under varied biophysical conditions. This allows the skeleton considerable …

A key objective of tissue engineering (TE) is to produce in vitro funcional grafts that can
replace damaged tissues or organs in patients. TE uses bioreactors, which are controlled …