The nano delivery systems and applications of mRNA

M Li, Y Li, S Li, L Jia, H Wang, M Li, J Deng… - European journal of …, 2022 - Elsevier
The current COVID-19 epidemic has greatly accelerated the application of mRNA
technology to our real world, and during this battle mRNA has proven it's unique advantages …

IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives

C Mancarella, K Scotlandi - Frontiers in cell and developmental …, 2020 - frontiersin.org
RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

K Masuda, Y Kuwano - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …

Comprehensive characterization of RNA processing factors in gastric cancer identifies a prognostic signature for predicting clinical outcomes and therapeutic …

S Lou, F Meng, X Yin, Y Zhang, B Han… - Frontiers in …, 2021 - frontiersin.org
RNA processing converts primary transcript RNA into mature RNA. Altered RNA processing
drives tumor initiation and maintenance, and may generate novel therapeutic opportunities …

Novel regulators of the IGF system in cancer

C Mancarella, A Morrione, K Scotlandi - Biomolecules, 2021 - mdpi.com
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes
cognate ligands, membrane receptors, ligand binding proteins and functional downstream …

The increasing diversity and complexity of the RNA-binding protein repertoire in plants

C Marondedze - Proceedings of the Royal Society B, 2020 - royalsocietypublishing.org
Post-transcriptional regulation has far-reaching implications on the fate of RNAs. It is gaining
increasing momentum as a critical component in adjusting global cellular transcript levels …

Liquid-liquid phase separation: Galectin-3 in nuclear speckles and ribonucleoprotein complexes

PG Voss, JL Wang - Experimental cell research, 2023 - Elsevier
Nuclear speckles are subcellular structures originally characterized by punctate
immunofluorescence staining of the monoclonal antibody SC35, which recognizes an …

Novel selective galectin-3 antagonists are cytotoxic to acute lymphoblastic leukemia

K Bum-Erdene, PM Collins, MW Hugo… - Journal of Medicinal …, 2022 - ACS Publications
Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that is
strongly implicated in cancer development, metastasis, and drug resistance. Galectin-3 …

Significance of alternative splicing in cancer cells

F Qi, Y Li, X Yang, YP Wu, LJ Lin, XM Liu - Chinese medical journal, 2020 - mednexus.org
Objective: Alternative splicing can generate various structural and functional protein
isoforms. Recently, accumulating evidence shows a relationship between alternative …

Spatial omics advances for in situ RNA biology

J Ren, S Luo, H Shi, X Wang - Molecular Cell, 2024 - cell.com
Spatial regulation of RNA plays a critical role in gene expression regulation and cellular
function. Understanding spatially resolved RNA dynamics and translation is vital for bringing …