HIF1α is a common component of pathways involved in the control of cellular metabolism
and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Classical activation of macrophages (M (LPS+ IFNγ)) elicits the expression of inducible nitric
oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial …

Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important
for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical …

The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Cell survival has been closely linked to both trophic growth factor signaling and cellular
metabolism. Such couplings have obvious physiologic and pathophysiologic implications …

Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the
dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRas G12V …

Macrophage activation and polarization are closely linked with metabolic rewiring, which is
required to sustain their biological functions. These metabolic alterations allow the …

One of the most common signatures of highly malignant tumors is their capacity to
metabolize more glucose to lactic acid than their tissues of origin. Hepatomas exhibiting this …

Mitochondria are essential organelles that act as metabolic hubs and signaling platforms
within the cell. Numerous mitochondrial functions, including energy metabolism, lipid …