Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells.
Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication …

Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers
remain the most common deadly disease worldwide. The aberrant DNA replication serves …

Background: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer, with
the incidence and mortality rates increasing every year. Despite the improvement of clinical …

Background & Aims We performed an integrated analysis to identify microRNAs (miRNAs)
and messenger RNAs (mRNAs) with altered expression in liver tumors from 3 mouse …

MCM6 is a significant DNA replication regulator that plays a crucial role in sustaining the cell
cycle. In many cancer cells, MCM6 expression is enhanced. For example, persistently …

Triple‐negative breast cancer (TNBC) liver metastasis is associated with poor prognosis and
low patient survival. It occurs when tumor cells disseminate from primary tumors, circulate in …

Background Clear cell renal cell carcinoma (ccRCC) accounts for 60-70% of renal cell
carcinoma (RCC) cases. Finding more therapeutic targets for advanced ccRCC is an urgent …

Background Gliomas account for 75% of all primary malignant brain tumors in adults and
result in high mortality. Accumulated evidence has declared the minichromosome …

Mini-chromosome maintenance (MCM) proteins are critical components of DNA-replication-
licensing factors. MCM8 is an MCM protein that exhibits oncogenic functions in several …

Minichromosome maintenance complex component 6 (MCM6), a member of the MCM
family, plays a pivotal role in DNA replication initiation and genome duplication of …