Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing,
and cancer development. It involves cooperation of signaling pathways, such as …

Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …

The blood-brain barrier (BBB) is composed of specialized endothelial cells that are critical to
neurological health. A key tool for understanding human BBB development and its role in …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Pluripotent stem cells constitute a platform to model disease and developmental processes
and can potentially be used in regenerative medicine. However, not all pluripotent cell lines …

There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using …

During early mouse embryogenesis, temporal and spatial regulation of gene expression and
cell signalling influences lineage specification, embryonic polarity, the patterning of tissue …