HMGB1: a double-edged sword and therapeutic target in the female reproductive system

Y Ren, D Zhu, X Han, Q Zhang, B Chen… - Frontiers in …, 2023 - frontiersin.org
HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin
associated transcription factor. It is present in the nucleus of eukaryotes and can be actively …

The Multiple Functions of HB-EGF in Female Reproduction and Related Cancer: Molecular Mechanisms and Targeting Strategies

Y Zhang, L Tang, H Liu, Y Cheng - Reproductive Sciences, 2024 - Springer
Heparin-binding growth factor (HB-EGF) is a member of the epidermal growth factor (EGF)
ligand family which has a crucial role in women's health. However, there is a lack of …

Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis

MY Li, Y Wu, HL Tang, Y Wang, B Li, YY He… - Advanced …, 2024 - Wiley Online Library
Embryo implantation and decidualization are crucial for a successful pregnancy. How the
inflammatory response is regulated during these processes is undefined. Pyroptosis is an …

Blastocyst-Derived Lactic Acid May Regulate S100A6 Expression and Function in Mouse Decidualization via Stimulation of Uterine Epithelial Arachidonic Acid …

MY Li, Y Wang, Y Wu, XY Zhao, ZS Yang, B Li… - Cells, 2024 - mdpi.com
(1) Background: Inflammatory responses are implicated in embryo implantation,
decidualization, pregnancy maintenance and labor. Both embryo implantation and …

The activation of cGAS‐STING pathway causes abnormal uterine receptivity in aged mice

ST Chen, WW Shi, F Ran, CK Liu, HN Luo, LJ Wu… - Aging …, 2024 - Wiley Online Library
Maternal age is one of the most important factors affecting the success of maternal
pregnancy. Uterine aging is the leading cause of pregnancy failure in older women …

Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release

CK Liu, YY He, ST Chen, WW Shi, Y Wang… - The FEBS …, 2024 - Wiley Online Library
Accumulating evidence shows that inflammation is essential for embryo implantation and
decidualization. Histamine, a proinflammatory factor that is present in almost all mammalian …

Laminin α5β2γ1 promotes uterine stromal cells' mesenchymal-epithelial transition during decidualization

PC Wang, T Fu, J Xie, Z Yang - 2023 - researchsquare.com
Decidualization is critical to pregnancy in primates and rodents. Endometrial stromal cells
undergo the mesenchymal-epithelial transition to transform into decidual stromal cells to …