Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. Its
relationship to chronic liver diseases, in particular cirrhosis, develops on a background of …

Cancer is a big challenge that has plagued the human beings for ages and one of the most
effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide …

Programmed cell death-ligand 1 (PD-L1) small interfering RNA (siRNA) achieves tumor
immunotherapy by restoring the immune response of T cells, but the efficacy of PD-1/PD-L1 …

Mitochondria, crucial regulators of inducing tumor cells apoptosis, can be treated as the
prime target for tumor therapy. The selective and responsive release of proapoptotic …

In recent years, the utilization of polysaccharides as targeted drug carriers has attracted
considerable attention. Herein, Angelica sinensis polysaccharide (ASP), a plant …

The complex tumor microenvironment (TME) makes it difficult for single chemotherapy to
achieve satisfactory therapeutic effects. Here, chitosan-coated hyaluronic acid micelles …

Doxorubicin belongs to the anthracycline chemical class of the drug and is one of the widely
used anticancer drugs. The common side effects of doxorubicin include vomiting, hair loss …

Highly effective delivery of therapeutic agents into target cells using nanocarriers and
subsequently rapid intracellular release are of great importance in cancer treatment. Here …

Current delivery strategies for cancer therapeutics commonly cause significant systemic side
effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor …