CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments

MP Jogalekar, RL Rajendran, F Khan… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell
therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell …

Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust

A Kumar, MA Nader, G Deep, A Baker - Pharmacological reviews, 2024 - Elsevier
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration

S Vermeulen, ZT Birgani, P Habibovic - Biomaterials, 2022 - Elsevier
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology

A Di Fazio, M Gullerova - British Journal of Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) are small non-coding RNAs (sncRNAs) essential for protein
translation. Emerging evidence suggests that tRNAs can also be processed into smaller …

Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS

E Carata, M Muci, S Di Giulio, S Mariano… - International journal of …, 2023 - mdpi.com
Neuroinflammation is a common pathological feature of amyotrophic lateral sclerosis (ALS).
Although scientific evidence to date does not allow defining neuroinflammation as an ALS …

[HTML][HTML] Spectacular role of epididymis and bio-active cargo of nano-scale exosome in sperm maturation: a review

W Ali, K Deng, Y Bian, Z Liu, H Zou - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The epididymis is responsible for post-testicular sperm maturation as it provides a favorable
environment for spermatozoa to gain the ability for movement and fertilization. The recent …

[HTML][HTML] Carbon emissions from Australian Sphagnum peatlands increase with feral horse (Equus caballus) presence

S Treby, SP Grover - Journal of Environmental Management, 2023 - Elsevier
Peatlands are globally significant carbon sinks, but when disturbed, have the potential to
release carbon back to the atmosphere as greenhouse gases. Feral horse populations in …

Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids

AC Buenafe, C Dorrell, AP Reddy, J Klimek… - Scientific Reports, 2022 - nature.com
Extracellular vesicles (EVs) are produced and released by both healthy and malignant cells
and bear markers indicative of ongoing biological processes. In the present study we utilized …

Extracellular Vesicle (EVs) associated non-coding RNAs in lung cancer and therapeutics

A Paramanantham, R Asfiya, S Das, G McCully… - International journal of …, 2022 - mdpi.com
Lung cancer is one of the most lethal forms of cancer, with a very high mortality rate. The
precise pathophysiology of lung cancer is not well understood, and pertinent information …

Biogenesis and delivery of extracellular vesicles: harnessing the power of EVs for diagnostics and therapeutics

J Yu, S Sane, JE Kim, S Yun, HJ Kim, KB Jo… - Frontiers in Molecular …, 2024 - frontiersin.org
Extracellular vesicles (EVs) are membrane-enclosed particles secreted by a variety of cell
types. These vesicles encapsulate a diverse range of molecules, including proteins, nucleic …