Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

Efficient and reliable manipulation of biological particles is crucial in medical diagnosis and
chemical synthesis. Inertial microfluidic devices utilizing passive hydrodynamic forces in the …

During metastasis, tumour cells navigating the vascular circulatory system—circulating
tumour cells (CTCs)—encounter capillary beds, where they start the process of …

Cancer mortality mainly arises from metastases, due to cells that escape from a primary
tumor, circulate in the blood as circulating tumor cells (CTCs), permeate across blood …

Cell/particle separation enabled by lab-on-a-chip (LOC) devices has been a promising
solution for separating target cells from the body fluids. Understanding the effects of …

We speculate ruptured circulating tumour cells (CTC) in capillaries could release a large
number of small extracellular vesicle-like vesicles, namely mechanically extruded sEV …

Mechanical properties of cells are not only unique intrinsic labels of cells, but also closely
related to the behaviors and functions of cells under various physiological and pathological …

Microfluidic systems have been widely explored based on microfluidic technology, and it has
been widely used for biomedical screening. The key parts are the fabrication of the base …

Circulating tumor cells (CTCs) play a crucial role in solid tumor metastasis, but obtaining
high purity and viability CTCs is a challenging task due to their rarity. Although various works …