Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Abstract Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may
develop symptoms and signs of disease (tuberculosis disease) or may have no clinical …

The mycobacterial envelope is unique, containing the so-called mycomembrane (MM)
composed of very-long chain fatty acids, mycolic acids (MA). Presently, the molecular …

M. tuberculosis and M. leprae are considered to be prototypical intracellular pathogens that
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …

Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …

Objectives To evaluate the effectiveness of available rapid diagnostic tests to identify
tuberculosis (TB) infection. Data sources Electronic databases were searched from 1975 to …

The RD1 genomic region is present in virulent strains of Mycobacterium tuberculosis (MTB),
missing from the vaccine strain M. bovis BCG, and its importance to virulence has been …