The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Platelets have traditionally been viewed as fragmentary mediators of coagulation. However,
recent molecular and cellular evidence suggests that they have multiple roles in host …

Inflammatory monocyte-derived effector cells play an important role in the pathogenesis of
numerous inflammatory diseases. However, no treatment option exists that is capable of …

Respiratory tract infections are an important cause of morbidity and mortality worldwide.
Chief among these are infections involving the lower airways. The opportunistic bacterial …

Streptococcus pneumoniae (the pneumococcus) is a major cause of mortality and morbidity
globally, and the leading cause of death in children under 5 years old. The pneumococcal …

Background Pneumococcus is one of the most common human airway pathogens that
causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic …

The lungs are an immunologically unique environment; they are exposed to innumerable
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …

Macrophages are professional phagocytes, indispensable for maintenance of tissue
homeostasis and integrity. Depending on their resident tissue, macrophages are exposed to …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally …

Macrophages are critical mediators of innate immune responses against bacteria. The Gram-
positive bacteria Streptococcus pneumoniae and Staphylococcus aureus express a range of …