Elemental and chemically specific X-ray fluorescence imaging of biological systems

MJ Pushie, IJ Pickering, M Korbas, MJ Hackett… - Chemical …, 2014 - ACS Publications
From the perspective of a chemist, biology confers a rich variety of roles on a number of
metal ions. It is widely agreed that a large fraction of the genomic output of living things …

Analytical methods for imaging metals in biology: from transition metal metabolism to transition metal signaling

CM Ackerman, S Lee, CJ Chang - Analytical chemistry, 2017 - ACS Publications
Metal elements represent some of the most fundamental chemical building blocks of life and
are required to sustain the growth, development, and sustenance of all living organisms and …

[HTML][HTML] The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse …

NJ Sylvain, MM Salman, MJ Pushie, H Hou… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Stroke is the second leading cause of death and the third leading cause of disability
globally. Edema is a hallmark of stroke resulting from dysregulation of water homeostasis in …

Practical review on the use of synchrotron based micro-and nano-X-ray fluorescence mapping and X-ray absorption spectroscopy to investigate the interactions …

HA Castillo-Michel, C Larue, AEP Del Real… - Plant Physiology and …, 2017 - Elsevier
The increased use of engineered nanomaterials (ENMs) in commercial products and the
continuous development of novel applications, is leading to increased intentional and …

X‐ray elemental mapping techniques for elucidating the ecophysiology of hyperaccumulator plants

A van Der Ent, WJ Przybyłowicz, MD de Jonge… - New …, 2018 - Wiley Online Library
Contents Summary 432 I. Introduction 433 II. Preparation of plant samples for X‐ray micro‐
analysis 433 III. X‐ray elemental mapping techniques 438 IV. X‐ray data analysis 442 V …

Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy

TS Zimmer, B David, DWM Broekaart… - Acta …, 2021 - Springer
Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species
(ROS) could represent an important, yet underappreciated, component of the epileptogenic …

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution

DJ Hare, EJ New, MD de Jonge… - Chemical Society Reviews, 2015 - pubs.rsc.org
Metal biochemistry drives a diverse range of cellular processes associated with
development, health and disease. Determining metal distribution, concentration and flux …

Synchrotron macro ATR-FTIR microspectroscopy for high-resolution chemical mapping of single cells

J Vongsvivut, D Pérez-Guaita, BR Wood, P Heraud… - Analyst, 2019 - pubs.rsc.org
Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy has been
used widely for probing the molecular properties of materials. Coupling a synchrotron …

Iron, copper, and zinc concentration in Aβ plaques in the APP/PS1 mouse model of Alzheimer's disease correlates with metal levels in the surrounding neuropil

SA James, QI Churches, MD de Jonge… - ACS chemical …, 2017 - ACS Publications
The metal ions of iron, copper, and zinc have long been associated with the aggregation of β-
amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to …

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

BF Popescu, JM Frischer, SM Webb, M Tham… - Acta …, 2017 - Springer
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for …