Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

Review on the time-dependent recruitment of inflammatory cells and unanswered questions
regarding inflammatory cells in the pathophysiology of ischemic stroke. Inflammation plays …

Some scholars have recently developed the concept of PANoptosis in the study of infectious
diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein …

A variety of animal models have been developed for modeling ischemic stroke. The middle
cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Immune and inflammatory responses actively modulate the pathophysiological processes of
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …

Abstract Ethnopharmacological relevance Buyang Huanwu Decoction (BYHWD) is used in
classical traditional Chinese medicine to prevent and treat cerebral ischemia. Glycosides …

Stroke is the fourth leading cause of death in the United States and the second most
common cause of death worldwide; stroke is also the leading cause of long-term disability …

Ischemic brain injury causes local inflammation, which involves activation of resident
microglia, leukocyte, and monocyte infiltration. Involvement of peripheral immune cells in …

Ischemic stroke is a leading cause of mortality and morbidity worldwide, with
neuroinflammation playing a key role in its pathophysiology. Microglia, the primary immune …