Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment

SS Carr, AJ Hooper, DR Sullivan, JR Burnett - Pathology, 2019 - Elsevier
Low density lipoprotein (LDL) is the predominant atherogenic lipoprotein particle in the
circulation. Conventionally, a fasting lipid profile has been used for atherosclerotic …

Update on the laboratory investigation of dyslipidemias

I Ramasamy - Clinica Chimica Acta, 2018 - Elsevier
The role of the clinical laboratory is evolving to provide more information to clinicians to
assess cardiovascular disease (CVD) risk and target therapy more effectively. Current …

LDL-C calculated by Friedewald, Martin-Hopkins, or NIH equation 2 versus beta-quantification: pooled alirocumab trials

HN Ginsberg, RS Rosenson, GK Hovingh… - Journal of Lipid …, 2022 - ASBMB
Accurate assessment of LDL-C levels is important, as they are often used for treatment
recommendations. For many years, plasma LDL-C levels were calculated using the …

[HTML][HTML] Cholesterol levels

Y Lee, WJ Siddiqui - 2019 - europepmc.org
Lipids are circulating as lipoproteins, consisting of unesterified cholesterol, triglycerides,
phospholipids, and protein. There are five major lipoproteins in blood:(1) chylomicrons;(2) …

Accuracy and clinical impact of estimating low-density lipoprotein-cholesterol at high and low levels by different equations

M Sampson, A Wolska, J Cole, R Zubirán, JD Otvos… - Biomedicines, 2022 - mdpi.com
New more effective lipid-lowering therapies have made it important to accurately determine
Low-density lipoprotein-cholesterol (LDL-C) at both high and low levels. LDL-C was …

Reducing lipid panel error allowances to improve the accuracy of cardiovascular risk stratification

J Cole, M Sampson, HE van Deventer… - Clinical …, 2023 - academic.oup.com
Background The standard lipid panel forms the backbone of atherosclerotic cardiovascular
disease risk assessment. Suboptimal analytical performance, along with biological …

Accuracy of low-density lipoprotein cholesterol estimation at very low levels

R Quispe, A Hendrani, MB Elshazly, ED Michos… - BMC medicine, 2017 - Springer
Background As the approach to low-density lipoprotein cholesterol (LDL-C) lowering
becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants …

An improved method for estimating low LDL-C based on the enhanced Sampson-NIH equation

TC Coverdell, M Sampson, R Zubirán, A Wolska… - Lipids in Health and …, 2024 - Springer
Background The accurate measurement of Low-density lipoprotein cholesterol (LDL-C) is
critical in the decision to utilize the new lipid-lowering therapies like PCSK9-inhibitors …

Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol< 70 mg/dL compared with a novel low-density …

SP Whelton, JW Meeusen, LJ Donato, AS Jaffe… - Journal of clinical …, 2017 - Elsevier
Background A number of national and international guidelines recommend treatment to low-
density lipoprotein cholesterol (LDL-C)< 70 mg/dL. Comparing the performance of the …

Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths

HY Hsu, MC Tsai, TL Yeh, LY Hsu, LC Hwang… - Scientific Reports, 2021 - nature.com
High baseline atherogenic lipid level has been an established risk factor for the risk of
cardiovascular events. Evidence concerning the role of lipid changes in cardiovascular and …