Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling

M Jeffrey, KJ Denny, J Lipman… - Intensive Care Medicine, 2023 - Springer
Infection results when a pathogen produces host tissue damage and elicits an immune
response. Critically ill patients experience immune activation secondary to both sterile and …

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing Organ-on-Chip, omics, immune cell phenotyping and in …

D Liu, JC Langston, B Prabhakarpandian… - Frontiers in Cellular …, 2024 - frontiersin.org
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis
is now defined as life-threatening organ dysfunction caused by a dysregulated host …

Screening of key genes of sepsis and septic shock using bioinformatics analysis

X Zeng, J Feng, Y Yang, R Zhao, Q Yu… - Journal of …, 2021 - Taylor & Francis
Objective: Sepsis is a disease associated with high mortality. We performed bioinformatic
analysis to identify key biomarkers associated with sepsis and septic shock. Methods: The …

Ginseng Sprouts Attenuate Mortality and Systemic Inflammation by Modulating TLR4/NF-κB Signaling in an LPS-Induced Mouse Model of Sepsis

SJ Hwang, JH Wang, JS Lee, JY Kang… - International Journal of …, 2023 - mdpi.com
Sepsis leads to multi-organ failure due to aggressive systemic inflammation, which is one of
the main causes of death clinically. This study aimed to evaluate whether ginseng sprout …

Diagnostic value of sIL-2R, TNF-α and PCT for sepsis infection in patients with closed abdominal injury complicated with severe multiple abdominal injuries

G Zhai, W Zhang, Z Xiang, LZ He, W Wang… - Frontiers in …, 2021 - frontiersin.org
Objective We aimed to evaluate the diagnostic value of soluble interleukin-2 receptor (sIL-
2R), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), and combined detection for sepsis …

[PDF][PDF] HMGB1 和vWF 等细胞因子对脓毒症患者病情严重程度及预后评估的意义

陈艳青, 黄潇, 孔桂青, 刘晓立, 田焕焕… - 中华危重病急救 …, 2020 - cccm-em120.com
目的探讨高迁移率族蛋白B1 (HMGB1), 血管性血友病因子(vWF) 等细胞因子对脓毒症患者病情
严重程度及预后的预测价值. 方法以2019 年1 月至6 月入住滨州医学院附属医院重症医学科 …

Electroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice

ZY Lv, YL Shi, GS Bassi, YJ Chen, LM Yin… - Journal of …, 2022 - Taylor & Francis
Purpose Sepsis is the main cause of death in intensive care unit. Maladaptive cytokine storm
and T-cell lymphopenia are critical prognosis predictors of sepsis. Electroacupuncture (EA) …

The TNF-α (–238 G/A) polymorphism could protect against development of severe sepsis

A Hugo Montes, E Valle-Garay, G Martin… - Innate …, 2021 - journals.sagepub.com
Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory
cytokines. Variations in the cytokine genes might modify their transcription or expression …

Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model

F Akther, H Fallahi, J Zhang, NT Nguyen, HT Ta - Lab on a Chip, 2024 - pubs.rsc.org
Platelets play an essential role in thrombotic processes. Recent studies suggest a direct link
between increased plasma glucose, lipids, and inflammatory cytokines with platelet …

Challenges and Advances in Biomarker Detection for Rapid and Accurate Sepsis Diagnosis: An Electrochemical Approach

DR Kumar, A Banaś, K Krukiewicz - Biosensors, 2024 - mdpi.com
Sepsis is a life-threatening condition with high mortality rates due to delayed treatment of
patients. The conventional methodology for blood diagnosis takes several hours, which …