Endoplasmic reticulum-targeting nanovehicles and methods for use thereof
CC Shieh, CL Yen, DB Shieh, S Jiang - US Patent 10,912,843, 2021 - Google Patents
A01K 677027(2006.01) A61K 9/00(2006.01) A61K 36/06(2006.01) A61K 36/22(2006.01)
A61K 36/23(2006.01) A61K 36/9062 (2006.01) A61K 31/05(2006.01) A61K …
A61K 36/23(2006.01) A61K 36/9062 (2006.01) A61K 31/05(2006.01) A61K …
Conjugation of lipophilic albumin-binding moiety to RNA for improved carrier-free in vivo pharmacokinetics and gene silencing
Provided herein are compounds and methods for gene silencing. The compound includes a
RNA directly conjugated to an albumin-binding group. The method includes administering a …
RNA directly conjugated to an albumin-binding group. The method includes administering a …