Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size

B Sinha, RH Müller, JP Möschwitzer - International journal of pharmaceutics, 2013 - Elsevier
The solubility dependent bioavailability problem has become a major hurdle in drug
development processes. Drug nanocrystals have been widely accepted by the …

Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis

L Liu, M Bi, Y Wang, J Liu, X Jiang, Z Xu, X Zhang - Nanoscale, 2021 - pubs.rsc.org
Artificial intelligence (AI) is an emerging technology with great potential, and its robust
calculation and analysis capabilities are unmatched by traditional calculation tools. With the …

Nanoparticle synthesis in microreactors

CX Zhao, L He, SZ Qiao, APJ Middelberg - Chemical Engineering Science, 2011 - Elsevier
Nanoparticles have been a research focus for more than two decades. The advent of
microfluidic technology provides alternative strategies for the synthesis of nanoparticles in …

Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling

HSM Ali, P York, AMA Ali, N Blagden - Journal of controlled release, 2011 - Elsevier
Recently, drug nanosuspensions have shown a potential for ophthalmic delivery. In this
study, a hydrocortisone (HC) nanosuspension (NS) was developed using microfluidic …

Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks

RA Hashad, RAH Ishak, S Fahmy, S Mansour… - International journal of …, 2016 - Elsevier
At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium
tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the …

Artificial intelligence application for rapid fabrication of size-tunable PLGA microparticles in microfluidics

SA Damiati, D Rossi, HN Joensson, S Damiati - Scientific reports, 2020 - nature.com
In this study, synthetic polymeric particles were effectively fabricated by combining modern
technologies of artificial intelligence (AI) and microfluidics. Because size uniformity is a key …

Microsystem advances through integration with artificial intelligence

HF Tsai, S Podder, PY Chen - Micromachines, 2023 - mdpi.com
Microfluidics is a rapidly growing discipline that involves studying and manipulating fluids at
reduced length scale and volume, typically on the scale of micro-or nanoliters. Under the …

Artificial intelligence in nanotechnology

GM Sacha, P Varona - Nanotechnology, 2013 - iopscience.iop.org
During the last decade there has been increasing use of artificial intelligence tools in
nanotechnology research. In this paper we review some of these efforts in the context of …

Deep insight into PEGylation of bioadhesive chitosan nanoparticles: sensitivity study for the key parameters through artificial neural network model

U Bozuyuk, NO Dogan, S Kizilel - ACS applied materials & …, 2018 - ACS Publications
Ionically cross-linked chitosan nanoparticles have great potential in nanomedicine due to
their tunable properties and cationic nature. However, low solubility of chitosan severely …

Artificial neural networks: theoretical background and pharmaceutical applications: a review

M Wesolowski, B Suchacz - journal of aoac international, 2012 - academic.oup.com
In recent times, there has been a growing interest in artificial neural networks, which are a
rough simulation of the information processing ability of the human brain, as modern and …