Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

Chromosome conformation capture-based methods such as Hi-C have become mainstream
techniques for the study of the 3D organization of genomes. These methods convert …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Endocrine therapy resistance frequently develops in estrogen receptor positive (ER+) breast
cancer, but the underlying molecular mechanisms are largely unknown. Here, we show that …

Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers.
However, we lack experimental models for validating their tumorigenic impact. Here, we …

In mammals, chromatin organization undergoes drastic reorganization during oocyte
development. However, the dynamics of three-dimensional chromatin structure in this …

Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which
is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs …

Chromatin organization undergoes drastic reconfiguration during gametogenesis. However,
the molecular reprogramming of three-dimensional chromatin structure in this process …