Recent advances of imidazole-containing derivatives as anti-tubercular agents
YL Fan, XH Jin, ZP Huang, HF Yu, ZG Zeng… - European journal of …, 2018 - Elsevier
Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …
Recent advances in DNA gyrase-targeted antimicrobial agents
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …
United States alone, it is responsible for the death of more than 20,000 people each year …
An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review
Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Thiazolyl-pyrazole derivatives as potential antimycobacterial agents
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit …
B Pakamwong, P Thongdee, B Kamsri… - Journal of Chemical …, 2024 - ACS Publications
Mycobacterium tuberculosis is the single most important global infectious disease killer and
a World Health Organization critical priority pathogen for development of new antimicrobials …
a World Health Organization critical priority pathogen for development of new antimicrobials …
Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach
MA Ejalonibu, SA Ogundare, AA Elrashedy… - International Journal of …, 2021 - mdpi.com
Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
DNA gyrase and topoisomerase IV are type IIa topoisomerases that are essential bacterial
enzymes required to oversee the topological state of DNA during transcription and …
enzymes required to oversee the topological state of DNA during transcription and …
Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …
disease which results in approximately 10 million incident cases and 1.4 million deaths …
Synthesis and antimycobacterial screening of new thiazolyl-oxazole derivatives
In the present study a series of 4-methyl-2-aryl-5-(2-aryl/benzyl thiazol-4-yl) oxazole (4a-v)
have been synthesized and evaluated for their preliminary antitubercular, antimicrobial and …
have been synthesized and evaluated for their preliminary antitubercular, antimicrobial and …