Signaling by the phosphoinositide 3-kinase family in immune cells
K Okkenhaug - Annual review of immunology, 2013 - annualreviews.org
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
PIK3CA in cancer: The past 30 years
Almost thirty years ago, PI3K was discovered as a lipid kinase associated with certain
oncoproteins. The first decade of research on PI3K saw the identification, purification and …
oncoproteins. The first decade of research on PI3K saw the identification, purification and …
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma
Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for
treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck …
treatment of breast cancers harboring canonical PIK3CA mutations. In head and neck …
In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas
MK McConechy, LN Hoang, MH Chui… - The Journal of …, 2015 - Wiley Online Library
Uterine carcinosarcoma is a clinically aggressive malignancy composed of a mix of
carcinomatous and sarcomatous elements. We performed targeted next‐generation …
carcinomatous and sarcomatous elements. We performed targeted next‐generation …
Predicting protein–membrane interfaces of peripheral membrane proteins using ensemble machine learning
A Chatzigoulas, Z Cournia - Briefings in Bioinformatics, 2022 - academic.oup.com
Abnormal protein–membrane attachment is involved in deregulated cellular pathways and
in disease. Therefore, the possibility to modulate protein–membrane interactions represents …
in disease. Therefore, the possibility to modulate protein–membrane interactions represents …
Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking
P Mellor, LA Furber, JNK Nyarko… - Biochemical …, 2012 - portlandpress.com
The p85α protein is best known as the regulatory subunit of class 1A PI3Ks
(phosphoinositide 3-kinases) through its interaction, stabilization and repression of p110 …
(phosphoinositide 3-kinases) through its interaction, stabilization and repression of p110 …
Design, synthesis, docking study, cytotoxicity evaluation, and PI3K inhibitory activity of Novel di-thiazoles, and bis (di-thiazoles)
A series of novel thiazole hybrids were designed and synthesized using a molecular
hybridization approach to develop more potent Pi3k inhibitors for cancer treatment. As a …
hybridization approach to develop more potent Pi3k inhibitors for cancer treatment. As a …
PI3 kinase inhibitors in the clinic: an update
JE Kurtz, I Ray-Coquard - Anticancer Research, 2012 - ar.iiarjournals.org
The phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin
(PI3K/AKT/mTOR) pathway has been identified as a key signaling pathway for important …
(PI3K/AKT/mTOR) pathway has been identified as a key signaling pathway for important …
PMIpred: a physics-informed web server for quantitative protein–membrane interaction prediction
N van Hilten, N Verwei, J Methorst, C Nase… - …, 2024 - academic.oup.com
Motivation Many membrane peripheral proteins have evolved to transiently interact with the
surface of (curved) lipid bilayers. Currently, methods to quantitatively predict sensing and …
surface of (curved) lipid bilayers. Currently, methods to quantitatively predict sensing and …
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors
Purpose: We describe herein a novel P447_L455 deletion in the C2 domain of PIK3CA in a
patient with an ER+ breast cancer with an excellent response to the PI3Kα inhibitor alpelisib …
patient with an ER+ breast cancer with an excellent response to the PI3Kα inhibitor alpelisib …