Current concepts in pharmacometabolomics, biomarker discovery, and precision medicine
RD Beger, MA Schmidt, R Kaddurah-Daouk - Metabolites, 2020 - mdpi.com
Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or
metabolome) to inform about how a subject will respond to drug treatment. Genome, gut …
metabolome) to inform about how a subject will respond to drug treatment. Genome, gut …
The use of metformin to increase the human healthspan
V Piskovatska, KB Storey, AM Vaiserman… - Reviews on New Drug …, 2020 - Springer
Metformin is a safe, effective and useful drug for glucose management in patients with
diabetes. However in recent years, more attention has been paid to the possibility of using …
diabetes. However in recent years, more attention has been paid to the possibility of using …
Vitamin B12 supplementation in diabetic neuropathy: a 1-year, randomized, double-blind, placebo-controlled trial
T Didangelos, E Karlafti, E Kotzakioulafi, E Margariti… - Nutrients, 2021 - mdpi.com
Aim: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12
(methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN) …
(methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN) …
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus
MM Hashem, A Esmael, AK Nassar, M El-Sherif - Scientific Reports, 2021 - nature.com
Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine,
and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This …
and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This …
Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study
M Alvarez, OR Sierra, G Saavedra… - Endocrine …, 2019 - ec.bioscientifica.com
Objective Vitamin B12 deficiency resulting from metformin use has been demonstrated in
multiple studies. In this study, we aimed to evaluate the prevalence of vitamin B12 deficiency …
multiple studies. In this study, we aimed to evaluate the prevalence of vitamin B12 deficiency …
Low serum vitamin B12 levels are associated with adverse lipid profiles in apparently healthy young Saudi women
S Al-Musharaf, GS Aljuraiban, S Danish Hussain… - Nutrients, 2020 - mdpi.com
An abnormal lipid profile is an independent risk factor for cardiovascular diseases. The
relationship between vitamin B12 deficiency and lipid profile is inconclusive, with most …
relationship between vitamin B12 deficiency and lipid profile is inconclusive, with most …
Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels?
M Wakeman, DT Archer - Diabetes, Metabolic Syndrome and …, 2020 - Taylor & Francis
Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …
Correlation between long-term use of metformin and incidence of NAFLD among patients with type 2 diabetes mellitus: A real-world cohort study
Background and aims Studies have demonstrated that the short-term use of metformin
benefits liver function among patients with type 2 diabetes mellitus (T2DM). However, few …
benefits liver function among patients with type 2 diabetes mellitus (T2DM). However, few …
Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan
Z Miyan, N Waris - BMJ Open Diabetes Research and Care, 2020 - drc.bmj.com
Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes
mellitus (T2DM) on metformin and without metformin. Methodology Between May 2018 and …
mellitus (T2DM) on metformin and without metformin. Methodology Between May 2018 and …
Vitamin B12 deficiency in patients with diabetes on metformin: Arab countries
JH Alhaji - Nutrients, 2022 - mdpi.com
Background: Diabetes is a global pandemic, especially in Arab countries. Aim: The goal of
this study was to review the published studies that were conducted to determine the …
this study was to review the published studies that were conducted to determine the …