RNA dependent RNA polymerases: insights from structure, function and evolution
RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …
viruses that is indispensable for replicating the genome as well as for carrying out …
RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target
Y Wang, V Anirudhan, R Du, Q Cui… - Journal of medical …, 2021 - Wiley Online Library
The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
Common and unique features of viral RNA-dependent polymerases
AJW Te Velthuis - Cellular and molecular life sciences, 2014 - Springer
Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …
these pathogens share little sequence similarity and use different replication and …
Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2
SAG Naidu, G Mustafa, RA Clemens… - Journal of Dietary …, 2023 - Taylor & Francis
The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-
19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic …
19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic …
RNA synthetic mechanisms employed by diverse families of RNA viruses
SM McDonald - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
RNA viruses are ubiquitous in nature, infecting every known organism on the planet. These
viruses can also be notorious human pathogens with significant medical and economic …
viruses can also be notorious human pathogens with significant medical and economic …
[HTML][HTML] Towards the Development of a Minigenome Assay for Species A Rotaviruses
O Diebold, S Zhou, CP Sharp, B Tesla, HW Chook… - Viruses, 2024 - mdpi.com
RNA virus polymerases carry out multiple functions necessary for successful genome
replication and transcription. A key tool for molecular studies of viral RNA-dependent RNA …
replication and transcription. A key tool for molecular studies of viral RNA-dependent RNA …
Group A Rotavirus VP1 Polymerase and VP2 Core Shell Proteins: Intergenotypic Sequence Variation and In Vitro Functional Compatibility
CL Steger, CE Boudreaux, LE LaConte… - Journal of …, 2019 - Am Soc Microbiol
Group A rotaviruses (RVAs) are classified according to a nucleotide sequence-based
system that assigns a genotype to each of the 11 double-stranded RNA (dsRNA) genome …
system that assigns a genotype to each of the 11 double-stranded RNA (dsRNA) genome …
Essential role of γ‐clade RNA‐dependent RNA polymerases in rice development and yield‐related traits is linked to their atypical polymerase activities regulating …
V Jha, A Narjala, D Basu, S TN, K Pachamuthu… - New …, 2021 - Wiley Online Library
Summary RNA‐dependent RNA polymerases (RDR) generate double‐stranded (ds) RNA
triggers for RNA silencing across eukaryotes. Among the three clades, α‐clade and β‐clade …
triggers for RNA silencing across eukaryotes. Among the three clades, α‐clade and β‐clade …
[HTML][HTML] Further characterisation of rotavirus cores: Ss (+) RNAs can be packaged in vitro but packaging lacks sequence specificity
U Desselberger, J Richards, L Tchertanov, J Lepault… - Virus Research, 2013 - Elsevier
Rotavirus (RV) cores were released from double-layered particles (DLPs) by high
concentrations of CaCl 2, purified and 'opened'by treatment with EDTA or EGTA. Under …
concentrations of CaCl 2, purified and 'opened'by treatment with EDTA or EGTA. Under …
Role of marine natural products in the development of antiviral agents against SARS-CoV-2: potential and prospects
DP Nagahawatta, NM Liyanage… - Marine Life Science & …, 2024 - Springer
A novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has surfaced and caused global concern owing to its ferocity. SARS-CoV-2 is the …
CoV-2), has surfaced and caused global concern owing to its ferocity. SARS-CoV-2 is the …