Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

The dynamic network of mitochondria fragments under stress allowing the segregation of
damaged mitochondria and, in case of persistent damage, their selective removal by …

The protein optic atrophy 1 (OPA1) is a dynamin-related protein associated with the inner
mitochondrial membrane and functions in mitochondrial inner membrane fusion and cristae …

The sequential flow of electrons in the respiratory chain, from a low reduction potential
substrate to O2, is mediated by protein-bound redox cofactors. In mitochondria, hemes …

Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for
virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed …

Currently, it is known that, in living systems, free radicals and other reactive oxygen and
nitrogen species play a double role, because they can cause oxidative damage and tissue …

Mitochondria are double-membraned highly dynamic organelles; the shape, location and
function of which are determined by a constant balance between opposing fusion and …

Mitochondrial respiration is an energy producing process that involves the coordinated
action of several protein complexes embedded in the inner membrane to finally produce …