The hydrolysis of GM2-ganglioside is unusual in its requirements for the correct synthesis,
processing, and ultimate combination of three gene products. Whereas two of these proteins …

When cultured in broth, fresh clinical isolates of the gram-negative periodontal pathogen
Actinobacillus actinomycetemcomitans form tenaciously adherent biofilm colonies on …

Enzymes are very important for biological processes in a living being, performing similar or
multiple tasks in and out of cells, tissues and other organisms at a particular location. The …

β-Hexosaminidase, a family 20 glycosyl hydrolase, catalyzes the removal of β-1, 4-linkedN-
acetylhexosamine residues from oligosaccharides and their conjugates. Heritable deficiency …

Breast-fed infants often have intestinal microbiota dominated by bifidobacteria in contrast to
formula-fed infants. We found that several bifidobacterial strains produce a lacto-N …

In humans, two major β-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a
heterodimer of subunits α and β (60% identity), whereas Hex B is a homodimer of β …

Bacteria in a biofilm are enmeshed in a self-synthesized extracellular polysaccharide matrix
that holds the bacteria together in a mass and firmly attaches the bacterial mass to the …

Lysosomal β-hexosaminidase A (Hex A) is essential for the degradation of GM2
gangliosides in the central and peripheral nervous system. Accumulation of GM2 leads to …

Siderophore-mediated iron acquisition has been well studied in many bacterial pathogens
because it contributes to virulence. In contrast, siderophore-mediated iron acquisition by …

SpHex, a retaining family 20 glycosidase from Streptomyces plicatus, catalyzes the
hydrolysis of N-acetyl-β-hexosaminides. Accumulating evidence suggests that the hydrolytic …