Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous
system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

Aquaporin (AQP) water channels are pivotal to renal water handling and therefore in the
regulation of body water homeostasis. However, beyond the kidney, AQPs facilitate water …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1), indoleamine 2, 3-dioxygenase 2 (IDO2),
and tryptophan 2, 3-dioxygenase (TDO) initiate the first step of the kynurenine pathway (KP) …

Differential diagnosis of brain lesion pathologies is complex, but it is nevertheless crucial for
appropriate clinical management. Advanced imaging methods, including diffusion-weighted …

The malignant brain cancer glioblastoma (GBM) contains groups of highly invasive cells that
drive tumor progression as well as recurrence after surgery and chemotherapy. The …

Aquaporin 4 (AQP4) is the most abundant water channel in the central nervous system
(CNS). Its expression is confined to non-neuronal glial cells, predominantly to astrocytes that …

Astrocyte endfeet are endowed with aquaporin‐4 (AQP4)‐based assemblies called
orthogonal arrays of particles (OAPs) whose function is still unclear. To investigate the …

Dysregulated cell migration and invasion are hallmarks of many disease states. This
dysregulated migratory behavior is influenced by the changes in expression of aquaporins …