Obtaining a particle size within the specifications for a pharmaceutical compound in an
industrial crystallization can be a challenging task. The events affecting the final particle size …

In recent years, continuous crystallization has gained interest in the pharmaceutical sector
due to its lower manufacturing costs and maintenance. However, controlling multiple critical …

A dissolution process featuring a hydrocyclone for the selective removal of fine crystals, ie,
an operation analyzed through modeling and experiments in earlier studies, is implemented …

Intermittent small particle removal is frequently used for particle property improvement in
batch crystallization processes. This is generally solved by partial dissolution cycles, which …

We present a novel dilution device designed for accurately and robustly diluting dense
suspensions to enable real-time particle characterization using optical imaging systems. The …

The active pharmaceutical ingredients of more than half of modern drugs are chiral
molecules. These are an important class of molecules, whose mirror images are not …