Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While
a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis …

Objectives Synovium is acutely affected following joint trauma and contributes to post-
traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and …

Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-
wide. Accumulating evidence attests to the important roles of the immune system in OA …

Objectives Single-cell level analysis of articular cartilage and meniscus tissues from human
healthy and osteoarthritis (OA) knees. Methods Single-cell RNA sequencing (scRNA-seq) …

Objective The synovial lymphatic system (SLS) removes catabolic factors from the joint.
Vascular endothelial growth factor C (VEGF‐C) and its receptor, VEGFR‐3, are crucial for …

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs),
characterized by ineffective hematopoiesis and frequent progression to leukemia. It has long …

Osteoarthritis (OA) treatment is limited by the lack of effective nonsurgical interventions to
slow disease progression. Here, we examined the contributions of the subchondral bone …

Although previous RNA sequencing methods have been widely used in orthopedic research
and have provided ideas for therapeutic strategies, the specific mechanisms of some …

Advances in the profiling of human joint tissues at single-cell resolution have provided
unique insights into the organization and function of these tissues in health and disease …