Functionalised macrocycles and medium‐sized rings have applications in a number of
scientific fields, ranging from medicinal chemistry and supramolecular chemistry, to catalysis …

Macrocycles have long been recognized as useful chemical entities for medicine, with
naturally occurring and synthetic macrocycles clinically approved for use as prescription …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

Natural peptides are an important class of chemical mediators, essential for most vital
processes. What limits the potential of the use of peptides as drugs is their low bioavailability …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Imidazole-1-sulfonyl azide and salts thereof are valuable reagents for diazo-transfer
reactions, most particularly conversion of primary amines to azides. The parent reagent and …

Macrocycles incorporating conformationally defined indoles are widely found in bioactive
natural products. However, the catalytic enantioselective synthesis of planar-chiral indoles …

Structurally diverse macrocycles and medium‐sized rings (9–24 membered scaffolds, 22
examples) can be generated through a telescoped acylation/ring‐expansion sequence …

Herein, we describe a practical streamlined two-component dual C–H activation
macrocyclization strategy entailing an in situ-generated directing group. The reaction mode …

Medium‐sized rings are widely considered to be under‐represented in biological screening
libraries for lead identification in medicinal chemistry. To help address this, a library of …