Mouse models of sarcopenia: classification and evaluation

W Xie, M He, D Yu, Y Wu, X Wang, S Lv… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

[HTML][HTML] Experimental models of sarcopenia: bridging molecular mechanism and therapeutic strategy

S Mankhong, S Kim, S Moon, HB Kwak, DH Park… - Cells, 2020 - mdpi.com
Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice

LH Chen, SS Chang, HY Chang, CH Wu… - Journal of cachexia …, 2022 - Wiley Online Library
Background Age‐related muscle dysfunctions are common disorders resulting in poor
quality of life in the elderly. Probiotic supplementation is a potential strategy for preventing …

Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model

C Andreani, C Bartolacci, M Guescini… - Oxidative Medicine …, 2018 - Wiley Online Library
Aging skeletal muscles are characterized by a progressive decline in muscle mass and
muscular strength. Such muscular dysfunctions are usually associated with structural and …

[HTML][HTML] Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)

Y Huang, B Wu, D Shen, J Chen, Z Yu… - International journal of …, 2021 - ncbi.nlm.nih.gov
As a systemic syndrome characterized by age-associated degenerative skeletal muscle
atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron …

[HTML][HTML] Age is just a number: progress and obstacles in the discovery of new candidate drugs for sarcopenia

HJ Kim, DW Jung, DR Williams - Cells, 2023 - mdpi.com
Sarcopenia is a disease characterized by the progressive loss of skeletal muscle mass and
function that occurs with aging. The progression of sarcopenia is correlated with the onset of …

[HTML][HTML] Targeting multiple mitochondrial processes by a metabolic modulator prevents sarcopenia and cognitive decline in SAMP8 mice

D Brunetti, E Bottani, A Segala, S Marchet… - Frontiers in …, 2020 - frontiersin.org
The age-dependent declines of skeletal muscle and cognitive functions often coexist in
elderly subjects. The underlying pathophysiological mechanisms share common features of …

Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice

HW Liu, YC Chang, YC Chan, SH Hu, MY Liu… - Biogerontology, 2020 - Springer
The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for
muscular aging research including sarcopenia, but its underlying mechanisms remain …

[HTML][HTML] Geniposide attenuates muscle atrophy via the inhibition of FoxO1 in senescence-accelerated mouse prone-8

PG Choi, SH Park, HY Jeong, HS Kim, JH Hahm… - Phytomedicine, 2024 - Elsevier
Background Geniposide (GP) is an iridoid glycoside that is present in nearly 40 species,
including Gardenia jasminoides Ellis. GP has been reported to exhibit neuroprotective …

[HTML][HTML] Coapplication of magnesium supplementation and vibration modulate macrophage polarization to attenuate sarcopenic muscle atrophy through PI3K/Akt …

C Cui, Z Bao, SKH Chow, RMY Wong, A Welch… - International Journal of …, 2022 - mdpi.com
Sarcopenia is an age-related geriatric syndrome characterized by the gradual loss of muscle
mass and function. Low-magnitude high-frequency vibration (LMHFV) was shown to be …